Down-regulation of SFRP1 in a mammary epithelial cell line
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Melissa Troester
PROVIDER: E-GEOD-15948 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis.
Gauger Kelly J KJ Hugh Jeremy M JM Troester Melissa A MA Schneider Sallie Smith SS
Cancer cell international 20090507
<h4>Background</h4>The Wnt family of secreted proteins is implicated in the regulation of cell fate during development, as well as in cell proliferation, morphology, and migration. Aberrant activation of the Wnt/beta-catenin signaling pathway leads to the development of several human cancers, including breast cancer. Secreted frizzled-related protein 1 (SFRP1) antagonizes this pathway by competing with the Frizzled receptor for Wnt ligands resulting in an attenuation of the signal transduction c ...[more]
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