The effect of hfq on global gene expression and virulence in Neisseria gonorrhoeae
Ontology highlight
ABSTRACT:
ORGANISM(S): Neisseria gonorrhoeae
SUBMITTER: Alexandra Friedrich
PROVIDER: E-GEOD-16046 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The effect of hfq on global gene expression and virulence in Neisseria gonorrhoeae.
Dietrich Manuela M Munke Rebekka R Gottschald Marion M Ziska Elke E Boettcher Jan Peter JP Mollenkopf Hans H Friedrich Alexandra A
The FEBS journal 20090818 19
Hfq is an RNA chaperone that functions as a pleiotropic regulator for RNA metabolism in bacteria. In several pathogenic bacteria, Hfq contributes indirectly to virulence by binding to riboregulators that modulate the stability or translation efficiency of RNA transcripts. To characterize the role of Hfq in the pathogenicity of Neisseria gonorrhoeae, we generated an N. gonorrhoeae hfq mutant. Infectivity and global changes in gene expression caused by the hfq mutation in N. gonorrhoeae strain MS1 ...[more]
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