Unknown,Transcriptomics,Genomics,Proteomics

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Analyzing the role of transcription elongation factors Spt4-5 in splicing


ABSTRACT: A set of 22 expts. aimed at identifying splicing events dependent upon on the Spt4-5 transcription elongation factors in yeast. Four spt mutants and an mRNA capping mutant were analyzed four times each, including biological and technical (dye-swap) replicates. Two wt vs wt expts. were also performed. Keywords = transcription/spt5/spt4/splicing/DEDS

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Mark Segal 

PROVIDER: E-GEOD-1610 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Analysis of a splice array experiment elucidates roles of chromatin elongation factor Spt4-5 in splicing.

Xiao Yuanyuan Y   Yang Yee H YH   Burckin Todd A TA   Shiue Lily L   Hartzog Grant A GA   Segal Mark R MR  

PLoS computational biology 20050916 4


Splicing is an important process for regulation of gene expression in eukaryotes, and it has important functional links to other steps of gene expression. Two examples of these linkages include Ceg1, a component of the mRNA capping enzyme, and the chromatin elongation factors Spt4-5, both of which have recently been shown to play a role in the normal splicing of several genes in the yeast Saccharomyces cerevisiae. Using a genomic approach to characterize the roles of Spt4-5 in splicing, we used  ...[more]

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