Ontology highlight
ABSTRACT:
ORGANISM(S): Cercocebus torquatus atys
SUBMITTER: Steven Bosinger
PROVIDER: E-GEOD-16147 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bosinger Steven E SE Li Qingsheng Q Gordon Shari N SN Klatt Nichole R NR Duan Lijie L Xu Luoling L Francella Nicholas N Sidahmed Abubaker A Smith Anthony J AJ Cramer Elizabeth M EM Zeng Ming M Masopust David D Carlis John V JV Ran Longsi L Vanderford Thomas H TH Paiardini Mirko M Isett R Benjamin RB Baldwin Don A DA Else James G JG Staprans Silvija I SI Silvestri Guido G Haase Ashley T AT Kelvin David J DJ
The Journal of clinical investigation 20091201 12
Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune activation, while pathogenic SIV infection of rhesus macaques (RMs) is associated with chronic immune activation. To elucidate the mechanisms underlying this intriguing phenotype, we used high-density oligonucleotide microarrays to longitudinally assess host gene expression in SIV-infected SMs and RMs. We found that acute SIV infection of SMs ...[more]