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Transcription profiling of human HL-60 leukemia cells after treatment with Curcumin and TCDD

ABSTRACT: Curcumin has antileukemic potential that is mediated by dfifferent pathways. Because we could not confirm that the Arylhydrocarbonreceptor, a ligand activated transcription factor, is involved in curcumins antileukemic effects, we performed microarray experiments to have an overall screening of the pathways affected by curcumin in HL-60 cells. We identified an involvement of the vitamin D receptor in the effects of curcumin on HL-60 cells by comparing our results with other experiments. Experiment Overall Design: HL-60 cells were treated for 24h with 100 ÂµM curcumin, 10 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or 0.5 % DMSO as control.

ORGANISM(S): Homo sapiens

SUBMITTER: Charlotte Esser

PROVIDER: E-GEOD-16160 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data of HL-60 leukemia cells after treatment with Curcumin and TCDD

Project description:Curcumin has antileukemic potential that is mediated by dfifferent pathways. Because we could not confirm that the Arylhydrocarbonreceptor, a ligand activated transcription factor, is involved in curcumins antileukemic effects, we performed microarray experiments to have an overall screening of the pathways affected by curcumin in HL-60 cells. We identified an involvement of the vitamin D receptor in the effects of curcumin on HL-60 cells by comparing our results with other experiments.

2009-05-19 | GSE16160 | GEO

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2013-12-01 | E-GEOD-50805 | biostudies-arrayexpress

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