Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Iouri Chepelev
PROVIDER: E-GEOD-16190 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nucleic acids research 20090615 16
Whole-genome resequencing is still a costly method to detect genetic mutations that lead to altered forms of proteins and may be associated with disease development. Since the majority of disease-related single nucleotide variations (SNVs) are found in protein-coding regions, we propose to identify SNVs in expressed exons of the human genome using the recently developed RNA-Seq technique. We identify 12 176 and 10 621 SNVs, respectively, in Jurkat T cells and CD4(+) T cells from a healthy donor. ...[more]