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Breast tumor gene expression profiling for assessment of sufficient tumor cells for microarray diagnostic

ABSTRACT: Gene expression profiling of breast cancer primary tumor was performed to identify gene expression that is related to the presence of sufficient tumor cells. These gene profile can be used for identification of tumor samples that are eligible for microarray diagnostics. A cohort of 403 early-stage primary breast cancer tumors was analyzed against a breast cancer reference pool

ORGANISM(S): Homo sapiens

SUBMITTER: Annuska Glas

PROVIDER: E-GEOD-16201 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A gene expression profile for detection of sufficient tumour cells in breast tumour tissue: microarray diagnosis eligibility.

Roepman Paul P Schuurman Arenda A Delahaye Leonie J M J LJ Witteveen Anke T AT Floore Arno N AN Glas Annuska M AM

BMC medical genomics 20090812

<h4>Background</h4>Microarray diagnostics of tumour samples is based on measurement of prognostic and/or predictive gene expression profiles. Typically, diagnostic profiles have been developed using bulk tumour samples with a sufficient amount of tumour cells (usually >50%). Consequentially, a diagnostic results depends on the minimal percentage of tumour cells within a sample. Currently, tumour cell percentage is assessed by conventional histopathological review. However, even for experienced p ...[more]

PMID: 19674463

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