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Transcription profiling of mouse gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 2, 10 and 21 days to identify the differential expression of genes

ABSTRACT: Microarray analysis of gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 48 hours, 10 days, and 3 weeks.

ORGANISM(S): Mus musculus

SUBMITTER: Mingming Zhao

PROVIDER: E-GEOD-1621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analysis of gene expression after transverse aortic constriction in mice.

Zhao Mingming M Chow Amy A Powers Jennifer J Fajardo Giovanni G Bernstein Daniel D

Physiological genomics 20040803 1

Cardiac hypertrophy is a compensatory response initially beneficial to heart function but can ultimately lead to cardiac decompensation. It is an integrated process involving multiple cellular signaling pathways and their cross talk. Microarray GeneChip technology is a powerful new tool to identify gene expression profiles of cardiac hypertrophy. To identify well-characterized as well as novel adaptive mechanisms, we utilized a murine model of compensated pressure overload hypertrophy (transvers ...[more]

PMID: 15292486

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