Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Avrum Spira
PROVIDER: E-GEOD-1650 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Spira Avrum A Beane Jennifer J Pinto-Plata Victor V Kadar Aran A Liu Gang G Shah Vishal V Celli Bartolome B Brody Jerome S JS
American journal of respiratory cell and molecular biology 20040916 6
The mechanism by which inhaled smoke causes the anatomic lesions and physiologic impairment of chronic obstructive pulmonary disease remains unknown. We used high-density microarrays to measure gene expression in severely emphysematous lung tissue removed from smokers at lung volume reduction surgery (LVRS) and normal or mildly emphysematous lung tissue from smokers undergoing resection of pulmonary nodules. Class prediction algorithms identified 102 genes that accurately distinguished severe em ...[more]