Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human lung tissue from severe emphysema versus normal or mild emphysema human patients


ABSTRACT: Comparison of severely emphysematous tissue removed at lung volume reduction surgery to that of normal or mildly emphysematous lung tissue resected from smokers with nodules suspicious for lung cancer. Data obtained from the 18 patients with severe emphysema and 12 patients with mild/no emphysema. Research may provide insights into the pathogenetic mechanisms involved in chronic obstructive pulmonary disease (COPD).

ORGANISM(S): Homo sapiens

SUBMITTER: Avrum Spira 

PROVIDER: E-GEOD-1650 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiling of human lung tissue from smokers with severe emphysema.

Spira Avrum A   Beane Jennifer J   Pinto-Plata Victor V   Kadar Aran A   Liu Gang G   Shah Vishal V   Celli Bartolome B   Brody Jerome S JS  

American journal of respiratory cell and molecular biology 20040916 6


The mechanism by which inhaled smoke causes the anatomic lesions and physiologic impairment of chronic obstructive pulmonary disease remains unknown. We used high-density microarrays to measure gene expression in severely emphysematous lung tissue removed from smokers at lung volume reduction surgery (LVRS) and normal or mildly emphysematous lung tissue from smokers undergoing resection of pulmonary nodules. Class prediction algorithms identified 102 genes that accurately distinguished severe em  ...[more]

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