Transcriptome analysis of Escherichia coli K-12 and ada mutant

ABSTRACT: Alkylation damage to DNA occurs when cells encounter alkylating agents in the environment or when active alkylators are generated by nitrosation of amino acids in metabolic pathways. To cope with DNA alkylation damage, cells have evolved genes that encode proteins with alkylation-specific DNA repair activities. It is notable that these repair systems are conserved from bacteria to humans. In Escherichia coli, cells exposed to a low concentration of an alkylating agent, such as N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate (MMS), show a remarkable increase in resistance to both the lethal and mutagenic effects of subsequent high-level challenge treatments with the same or other alkylating agents. This increased resistance has been known as “adaptive response”

ORGANISM(S): Escherichia coli K-12

SUBMITTER: SangYup Lee 

PROVIDER: E-GEOD-16565 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress