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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse retina from four genotypes: +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl at P14 and P28

ABSTRACT: Rorb is essential for rod photoreceptor development in the mouse retina. Using Affymetrix mouse GeneChips, we have generated expression profiles of the +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl retina at P14 and P28. In this dataset, we include the expression data obtained from retina of wt and mutants. These data are used to obtain 1189 genes that are differentially expressed in Rorb-/- vs wt. Experiment Overall Design: 31 total samples were analyzed

ORGANISM(S): Mus musculus

SUBMITTER: Douglas Forrest

PROVIDER: E-GEOD-16585 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.

Jia Li L Oh Edwin C T EC Ng Lily L Srinivas Maya M Brooks Matthew M Swaroop Anand A Forrest Douglas D

Proceedings of the National Academy of Sciences of the United States of America 20090924 41

Rods and cones are morphologically and developmentally distinct photoreceptor types with different functions in vision. Cones mediate daylight and color vision and in most mammals express M and S opsin photopigments for sensitivity to medium-long and short light wavelengths, respectively. Rods mediate dim light vision and express rhodopsin photopigment. The transcription factor networks that direct differentiation of each photoreceptor type are incompletely defined. Here, we report that Rorb(-/- ...[more]

PMID: 19805139

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Expression profiling of P14 and P28 mouse retina from 4 genotypes: +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl

Project description:Rorb is essential for rod photoreceptor development in the mouse retina. Using Affymetrix mouse GeneChips, we have generated expression profiles of the +/+, Rorb-/- , +/+;CrxpNrl and Rorb-/-;CrxpNrl retina at P14 and P28. In this dataset, we include the expression data obtained from retina of wt and mutants. These data are used to obtain 1189 genes that are differentially expressed in Rorb-/- vs wt.

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