Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Scott Dindot
PROVIDER: E-GEOD-16588 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Dindot Scott V SV Person Richard R Strivens Mark M Garcia Rejinaldo R Beaudet Arthur L AL
Genome research 20090619 8
Genomic imprinting arises from allele-specific epigenetic modifications that are established during gametogenesis and that are maintained throughout somatic development. These parental-specific modifications include DNA methylation and post-translational modifications to histones, which create allele-specific active and repressive domains at imprinted regions. Through the use of a high-density genomic tiling array, we generated DNA and histone methylation profiles at 11 imprinted gene clusters i ...[more]