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Epigenetic profiling at mouse imprinted gene clusters

ABSTRACT: Epigenetic profiling of DNA methylation, histone H3 lysine 4 trimethylation and histone H3 lysine 9 trimethylation at imprinted gene clusters in the mouse. Imprinted control regions were identified by comparing DNA and histone methylation patterns between sperm, heart and cerebellum.

ORGANISM(S): Mus musculus

SUBMITTER: Scott Dindot

PROVIDER: E-GEOD-16588 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions.

Dindot Scott V SV Person Richard R Strivens Mark M Garcia Rejinaldo R Beaudet Arthur L AL

Genome research 20090619 8

Genomic imprinting arises from allele-specific epigenetic modifications that are established during gametogenesis and that are maintained throughout somatic development. These parental-specific modifications include DNA methylation and post-translational modifications to histones, which create allele-specific active and repressive domains at imprinted regions. Through the use of a high-density genomic tiling array, we generated DNA and histone methylation profiles at 11 imprinted gene clusters i ...[more]

PMID: 19542493

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