Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Tumor T8 Sectors

ABSTRACT: The following CGH experiments were conducted on five sectors (S1-S5) from a single primary ductal carcinoma tumor (T8) using the Sector-Ploidy-Profiling (SPP) Approach. SPP involves macro-dissecting the tumor, flow-sorting nuclei by differences in total genomic DNA content and profiling the genome of the tumor subpopulations. The genomic DNA from each tumor subpopulation was labeled with Cy5 and hybridized to an 85K Bgl2 ROMA Microarray. A normal reference male fibroblast was labeled with Cy3 as a control. Samples were dye-swapped and the experiments were conducted in color-reversal. The value data repesents a log ratio of the mean of two dye-swapped samples

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Navin

PROVIDER: E-GEOD-16605 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

High-resolution nucleosome mapping reveals transcription-dependent promoter packaging.

Weiner Assaf A Hughes Amanda A Yassour Moran M Rando Oliver J OJ Friedman Nir N

Genome research 20091021 1

Genome-wide mapping of nucleosomes has revealed a great deal about the relationships between chromatin structure and control of gene expression, and has led to mechanistic hypotheses regarding the rules by which chromatin structure is established. High-throughput sequencing has recently become the technology of choice for chromatin mapping studies, yet analysis of these experiments is still in its infancy. Here, we introduce a pipeline for analyzing deep sequencing maps of chromatin structure an ...[more]

PMID: 19846608

Dataset Information

Tumor T8 Sectors

Publications

High-resolution nucleosome mapping reveals transcription-dependent promoter packaging.

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