Identification of novel gene amplification events in breast cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wakefield Lalage
PROVIDER: E-GEOD-16619 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA.
Kadota Mitsutaka M Sato Misako M Duncan Beverly B Ooshima Akira A Yang Howard H HH Diaz-Meyer Natacha N Gere Sheryl S Kageyama Shun-Ichiro S Fukuoka Junya J Nagata Takuya T Tsukada Kazuhiro K Dunn Barbara K BK Wakefield Lalage M LM Lee Maxwell P MP
Cancer research 20090825 18
To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes include the well-known oncogenes ERBB2, FGFR1, MYC, CCND1, and PIK3CA, whereas other known oncogenes that are amplified, although less frequently, include CCND2, EGFR, FGFR2, and NOTCH3. ...[more]
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