Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shane Crotty
PROVIDER: E-GEOD-16697 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Johnston Robert J RJ Poholek Amanda C AC DiToro Daniel D Yusuf Isharat I Eto Danelle D Barnett Burton B Dent Alexander L AL Craft Joe J Crotty Shane S
Science (New York, N.Y.) 20090716 5943
Effective B cell-mediated immunity and antibody responses often require help from CD4+ T cells. It is thought that a distinct CD4+ effector T cell subset, called T follicular helper cells (T(FH)), provides this help; however, the molecular requirements for T(FH) differentiation are unknown. We found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo T(FH) differentiation and T cell help to B cells in mice. In contrast, the transcription ...[more]