Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Xin Ye
PROVIDER: E-GEOD-16707 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell 20091001 2
Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause retinal hypovascularization, but the mechanisms by which Norrin/Fz4/Lrp signaling controls vascular development have not been defined. Using mouse genetic and cell culture models, we show that loss of Fz4 signaling in endothelial cells causes defective vascular growth, which leads to chronic but reversible silencin ...[more]