Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ruth Yu
PROVIDER: E-GEOD-16723 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genes & development 20101124 24
In the macrophage, toll-like receptors (TLRs) are key sensors that trigger signaling cascades to activate inflammatory programs via the NF-κB gene network. However, the genomic network targeted by TLR/NF-κB activation and the molecular basis by which it is restrained to terminate activation and re-establish quiescence is poorly understood. Here, using chromatin immunoprecipitation sequencing (ChIP-seq), we define the NF-κB cistrome, which is comprised of 31,070 cis-acting binding sites responsiv ...[more]