Dataset Information
RNAi knock down of ATM, p53 Rel_A subunit of NFkB or LacZ in human HEK293 cells treated with the radiomimetic drug NCS
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ran Elkon
PROVIDER: E-GEOD-1676 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.
Genome biology 20050413 5
<h4>Background</h4>Gene-expression microarrays and RNA interferences (RNAi) are among the most prominent techniques in functional genomics. The combination of the two holds promise for systematic, large-scale dissection of transcriptional networks. Recent studies, however, raise the concern that nonspecific responses to small interfering RNAs (siRNAs) might obscure the consequences of silencing the gene of interest, throwing into question the ability of this experimental strategy to achieve prec ...[more]
