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Molecular characterization of head and neck cancer cell model genomes

ABSTRACT: To provide full characterization of genome changes in six commonly used head and neck cancer cell lines. These data will serve as an excellent resource when designing future experiments that attempt to model HNSCC behaviour. Six commonly used ATCC head and neck cancer cell lines are analyzed.

ORGANISM(S): Homo sapiens

SUBMITTER: Ivy Tsui

PROVIDER: E-GEOD-16872 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative molecular characterization of head and neck cancer cell model genomes.

Tsui Ivy F L IF Garnis Cathie C

Head & neck 20100901 9

<h4>Background</h4>Cell lines are invaluable model systems for the investigation of cancer. Knowledge of the molecular alterations that exist within cell models is required to define the mechanisms governing cellular phenotypes.<h4>Methods</h4>Five tongue squamous cell carcinomas cell lines and 1 submaxillary salivary gland epidermoid carcinoma cell line were analyzed for copy number and mRNA expression by tiling-path DNA microarrays and Agilent Whole Human Genome Oligoarrays, respectively.<h4>R ...[more]

PMID: 20014447

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