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Microarray analysis of iris gene expression in mice with mutations relevant to glaucoma

ABSTRACT: Several ocular diseases involve the iris, notably including oculocutaneous albinism, pigment dispersion syndrome, and exfoliation syndrome. To screen for candidate genes that may be active in these diseases, genome-wide iris gene expression patterns were comparatively analyzed from mouse models of these conditions. Irides were obtained from healthy C57Bl/6J, B6-Lystbg-J/J which carry a mutation in the Lyst gene, B6(Cg)-TyrC-2J/J which carry a mutation in the tyr gene, and B6.D2-Tryp1bGpnmbR150X/Sj with mutations in both Tryp1 and Gpnmb. Four eyes from two mice were pooled for one sample. Three samples were prepared for each strain.

ORGANISM(S): Mus musculus

SUBMITTER: Colleen Trantow

PROVIDER: E-GEOD-16994 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analysis of iris gene expression in mice with mutations influencing pigmentation.

Trantow Colleen M CM Cuffy Tryphena L TL Fingert John H JH Kuehn Markus H MH Anderson Michael G MG

Investigative ophthalmology & visual science 20110105 1

<h4>Purpose</h4>Several ocular diseases involve the iris, notably including oculocutaneous albinism, pigment dispersion syndrome, and exfoliation syndrome. To screen for candidate genes that may contribute to the pathogenesis of these diseases, genome-wide iris gene expression patterns were comparatively analyzed from mouse models of these conditions.<h4>Methods</h4>Iris samples from albino mice with a Tyr mutation, pigment dispersion-prone mice with Tyrp1 and Gpnmb mutations, and mice resemblin ...[more]

PMID: 20739468

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