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Transcription profiling of human fibroblasts from subjects with age-related macular degeneration

ABSTRACT: Age-related macular degeneration has a strong epidemiological association with cardiovascular disease. One pathogenic hypothesis that applies to both diseases is the concept of an abnormal cellular response to injury resulting in a disease phenotype. It has been hypothesized that this phenotype is also present in dermal fibroblasts. This study tests this hypothesis by examination of the expression profiles of fibroblasts obtained from diseased patients and subjected to sublethal cell injury.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Eric Hoffman

PROVIDER: E-GEOD-1719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Macular Degeneration

Project description:Age-related macular degeneration has a strong epidemiological association with cardiovascular disease. One pathogenic hypothesis that applies to both diseases is the concept of an abnormal cellular response to injury resulting in a disease phenotype. It has been hypothesized that this phenotype is also present in dermal fibroblasts. This study tests this hypothesis by examination of the expression profiles of fibroblasts obtained from diseased patients and subjected to sublethal cell injury. Keywords: other

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Molecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration

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Molecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration

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Project description:NEI CIDR Etiologic Studies of Macular Degeneration

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NEI CIDR Etiologic Studies of Macular Degeneration

Project description:NEI CIDR Etiologic Studies of Macular Degeneration

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