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Transcription profiling of S. cerevisiae chemostat cultures limiting for carbon, nitrogen, phosphorus, sulfur under aerobic and anaerobic conditions


ABSTRACT: The goal of this study was to study this interaction by analyzing genome-wide transcriptional responses to four different nutrient-limitation regimes under aerobic and anaerobic conditions in chemostat cultures of S. cerevisiae. This ‘two-dimensional’ approach resulted in a new, robust set of ‘anaerobic’ and ‘aerobic’ signature transcripts for S. cerevisiae, as well as to a refinement of previous reports on nutrient-responsive genes. Moreover, the identification of genes regulated both by nutrient and oxygen availability provided new insight in cross-regulated network and hierarchy in the control of gene expression.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Jean-Marc Daran 

PROVIDER: E-GEOD-1723 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Two-dimensional transcriptome analysis in chemostat cultures. Combinatorial effects of oxygen availability and macronutrient limitation in Saccharomyces cerevisiae.

Tai Siew Leng SL   Boer Viktor M VM   Daran-Lapujade Pascale P   Walsh Michael C MC   de Winde Johannes H JH   Daran Jean-Marc JM   Pronk Jack T JT  

The Journal of biological chemistry 20041020 1


Genome-wide analysis of transcriptional regulation is generally studied by determining sets of "signature transcripts" that are up- or down-regulated relative to a reference situation when a single culture parameter or genetic modification is changed. This approach is especially relevant for defining small subsets of transcripts for use in high throughput, cost-effective diagnostic analyses. However, this approach may overlook the simultaneous control of transcription by more than one environmen  ...[more]

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