Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Expression data from B6C3F1 mice treated with baclofen

ABSTRACT: Mice were treated with either 100mg/kg baclofen or 0.5% methylcellulose alone by oral gavage for 1 or 5 days. Mice were sacrificed by cervical dislocation after either a single dose (1day) or 5 daily doses (5 days) of either baclofen or 0.5% methylcellulose two hours after the last dose. The bone marrow from the right humerus, a portion of the left lateral liver lobe and half a cross-section of the spleen were harvested and the RNA was isolated from these tissues using standard Qiagen reagents. Standard Affymetrix protocols were used for GeneChip probe preparations. 59 arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Petra Koza-Taylor 

PROVIDER: E-GEOD-17266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach was undertaken using transcriptomics and Causal Network Modeling from mice treated with 2-butoxyethanol (2-BE). 2-BE is a hemolytic agent that induces hemangiosarcomas in mice. We hypothesized that the hemolysis induced by 2-BE would result in local tissue hypoxia, a well-documented trigger for endothelial cell proliferation leading to hema  ...[more]

Similar Datasets

Transcriptomics Expression data from B6C3F1 mice treated with 2-butoxyethanol
2010-01-10 | E-GEOD-17794 | biostudies-arrayexpress
Transcriptomics Expression data from B6C3F1 mice treated with reduced oxygen
2010-01-10 | E-GEOD-17796 | biostudies-arrayexpress
Transcriptomics Expression data from B6C3F1 mice treated with 2-butoxyethanol and reduced oxygen
2010-01-11 | E-GEOD-17880 | biostudies-arrayexpress
Transcriptomics Effect of LXR agonist T0901317 on the intestinal transcriptome in mice.
2020-10-27 | GSE110528 | GEO
Transcriptomics Expression data from B6C3F1 mice treated with baclofen
2010-01-12 | GSE17266 | GEO
Transcriptomics Gene expression profiling of five diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4, DHL6, LY7, HBL1 and U2932, treated with the SYK inhibitor, R406
2013-08-31 | E-GEOD-43510 | biostudies-arrayexpress
Transcriptomics Time course gene expression profiling of five diffuse large B-cell lymphoma cell lines following JQ1 treatment
2013-12-10 | E-GEOD-45630 | biostudies-arrayexpress
Transcriptomics Transcriptional profiling of human myxoid liposarcoma xenografts treated with trabectedin
2013-12-10 | E-MTAB-1809 | biostudies-arrayexpress
Transcriptomics Gene expression profiling of two diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4 and DHL6, treated with the SYK inhibitor, R406
2013-12-31 | E-GEOD-34176 | biostudies-arrayexpress
Transcriptomics Transcriptional profiling of CD1 mouse liver after 28 days and 90 days of daily administration of Phenobarbital in vivo
2018-04-27 | GSE68361 | GEO