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Transcription profiling of blood samples from human patients with severe acute respiratory syndrome (SARS)

ABSTRACT: To understand the host response to this pathogen, we investigated the gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from SARS patients, and compared with healthy controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Jayapal Manikandan

PROVIDER: E-GEOD-1739 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome.

Reghunathan Renji R Jayapal Manikandan M Hsu Li-Yang LY Chng Hiok-Hee HH Tai Dessmon D Leung Bernard P BP Melendez Alirio J AJ

BMC immunology 20050118

<h4>Background</h4>Severe acute respiratory syndrome (SARS) emerged in later February 2003, as a new epidemic form of life-threatening infection caused by a novel coronavirus. However, the immune-pathogenesis of SARS is poorly understood. To understand the host response to this pathogen, we investigated the gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from SARS patients, and compared with healthy controls.<h4>Results</h4>The number of differentially expressed ge ...[more]

PMID: 15655079

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