Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Pregnancy changes expression in peripheral blood mononuclear cells of Multiple Sclerosis (MS) patients

ABSTRACT: Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a MS signature comparing female MS specimens before pregnancy with respect to female MS specimens at ninth month pregnancy. Subjects were followed in the outpatients clinic and blood was collected before pregnancy and at the following time points during pregnancy: first trimester (gestational age at sampling 12 weeks), second trimester (24 weeks), and third trimester (36 weeks). Before-pregnancy samples were obtained in a treatment-free period and after anticonceptional drug withdrawal. Peripheral blood mononuclear cells (PBMCs) obtained from 17 women (8 MS patients before pregnancy and 9 MS patients at 9th month pregnancy) were analyzed by oligonucleotide microarray technology.

ORGANISM(S): Homo sapiens

SUBMITTER: Raffaele Calogero 

PROVIDER: E-GEOD-17410 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Learning from nature: pregnancy changes the expression of inflammation-related genes in patients with multiple sclerosis.

Gilli Francesca F   Lindberg Raija L P RL   Valentino Paola P   Marnetto Fabiana F   Malucchi Simona S   Sala Arianna A   Capobianco Marco M   di Sapio Alessia A   Sperli Francesca F   Kappos Ludwig L   Calogero Raffaele A RA   Bertolotto Antonio A  

PloS one 20100129 1

<h4>Background</h4>Pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood.<h4>Methodology</h4>We conducted a genome-wide transcription analysis in peripheral blood mononuclear cells (PBMCs) from 12 women (7 MS patients and 5 healthy controls) followed during their pregnancy. Samples were obtained before, during (i.e. at the third, sixth, and ninth month of ge  ...[more]

Similar Datasets

Transcriptomics Transcription signature of Multiple Sclerosis in peripheral blood mononuclear cells.
2010-01-10 | E-GEOD-17393 | biostudies-arrayexpress
Transcriptomics Pregnancy changes expression in peripheral blood mononuclear cells of healthy donors
2010-01-09 | E-GEOD-17409 | biostudies-arrayexpress
Proteomics Quantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry
2018-11-21 | PXD009025 | Pride
Transcriptomics Pregnancy changes expression in peripheral blood mononuclear cells of Multiple Sclerosis (MS) patients
2010-01-10 | GSE17410 | GEO
Proteomics Salivary proteome signatures in the early and middle stages of human pregnancy with term birth outcome
2020-09-28 | PXD014800 | Pride
Transcriptomics Epigenome-wide DNA methylation profiling in CD4+ and CD8+ T cells from patients with multiple sclerosis and healthy controls followed during (1st, 2nd and 3rd trimester) and after pregnancy.
2023-09-23 | E-MTAB-12250 | biostudies-arrayexpress
Transcriptomics Time series ATAC-seq of Th1 differentiation: The effect of Progesterone on Th1 differentiation?
2021-09-09 | E-MTAB-10444 | biostudies-arrayexpress
Transcriptomics Characterization of human plasma pregnancy-associated miRNAs at first trimester and their association with pregnancy complications [cohort 1]
2022-10-24 | GSE216275 | GEO
Transcriptomics Time series RNA-seq of Th1 differentiation: The effect of Progesterone on Th1 differentiation?
2021-09-09 | E-MTAB-10423 | biostudies-arrayexpress
Transcriptomics Epigenome-wide DNA methylation profiling in CD4+ and CD8+ T cells from patients with multiple sclerosis and healthy controls followed during (1st, 2nd and 3rd trimester) and after pregnancy
2023-08-02 | E-MTAB-12260 | biostudies-arrayexpress