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Pregnancy changes expression in peripheral blood mononuclear cells of Multiple Sclerosis (MS) patients

ABSTRACT: Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a MS signature comparing female MS specimens before pregnancy with respect to female MS specimens at ninth month pregnancy. Subjects were followed in the outpatients clinic and blood was collected before pregnancy and at the following time points during pregnancy: first trimester (gestational age at sampling 12 weeks), second trimester (24 weeks), and third trimester (36 weeks). Before-pregnancy samples were obtained in a treatment-free period and after anticonceptional drug withdrawal. Peripheral blood mononuclear cells (PBMCs) obtained from 17 women (8 MS patients before pregnancy and 9 MS patients at 9th month pregnancy) were analyzed by oligonucleotide microarray technology.

ORGANISM(S): Homo sapiens

SUBMITTER: Raffaele Calogero 

PROVIDER: E-GEOD-17410 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Learning from nature: pregnancy changes the expression of inflammation-related genes in patients with multiple sclerosis.

Gilli Francesca F   Lindberg Raija L P RL   Valentino Paola P   Marnetto Fabiana F   Malucchi Simona S   Sala Arianna A   Capobianco Marco M   di Sapio Alessia A   Sperli Francesca F   Kappos Ludwig L   Calogero Raffaele A RA   Bertolotto Antonio A  

PloS one 20100129 1

<h4>Background</h4>Pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood.<h4>Methodology</h4>We conducted a genome-wide transcription analysis in peripheral blood mononuclear cells (PBMCs) from 12 women (7 MS patients and 5 healthy controls) followed during their pregnancy. Samples were obtained before, during (i.e. at the third, sixth, and ninth month of ge  ...[more]

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