Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of human Downs syndrome with acute lymphoblastic pediatric leukemia (DS-ALL) patients

ABSTRACT: DS-ALL is a highly heterogeneous disease with predominance of an aberrant exp. of CRLF2 cooperating with mutated JAK2; Acute lymphoblastic pediatric leukemia specimens of Down's syndrome are examined for gene expression profiles and specific genetic aberrations. Gene expression profiling and specific genetic variation analysis identify novel pathways involved in DS-ALL pathogenesis. Experiment Overall Design: Gene expression profile analysis and specific genetic data are integrated to find characteristics of DS-ALL's

ORGANISM(S): Homo sapiens

SUBMITTER: Libi Hertzberg

PROVIDER: E-GEOD-17459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.

Hertzberg Libi L Vendramini Elena E Ganmore Ithamar I Cazzaniga Gianni G Schmitz Maike M Chalker Jane J Shiloh Ruth R Iacobucci Ilaria I Shochat Chen C Zeligson Sharon S Cario Gunnar G Stanulla Martin M Strehl Sabine S Russell Lisa J LJ Harrison Christine J CJ Bornhauser Beat B Yoda Akinori A Rechavi Gideon G Bercovich Dani D Borkhardt Arndt A Kempski Helena H te Kronnie Geertruy G te Kronnie Geertruy G Bourquin Jean-Pierre JP Domany Eytan E Izraeli Shai S

Blood 20091124 5

We report gene expression and other analyses to elucidate the molecular characteristics of acute lymphoblastic leukemia (ALL) in children with Down syndrome (DS). We find that by gene expression DS-ALL is a highly heterogeneous disease not definable as a unique entity. Nevertheless, 62% (33/53) of the DS-ALL samples analyzed were characterized by high expression of the type I cytokine receptor CRLF2 caused by either immunoglobulin heavy locus (IgH@) translocations or by interstitial deletions cr ...[more]

PMID: 19965641

Dataset Information

Transcription profiling of human Downs syndrome with acute lymphoblastic pediatric leukemia (DS-ALL) patients

Publications

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.

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