Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human Downs syndrome with acute lymphoblastic pediatric leukemia (DS-ALL) patients


ABSTRACT: DS-ALL is a highly heterogeneous disease with predominance of an aberrant exp. of CRLF2 cooperating with mutated JAK2; Acute lymphoblastic pediatric leukemia specimens of Down's syndrome are examined for gene expression profiles and specific genetic aberrations. Gene expression profiling and specific genetic variation analysis identify novel pathways involved in DS-ALL pathogenesis. Experiment Overall Design: Gene expression profile analysis and specific genetic data are integrated to find characteristics of DS-ALL's

ORGANISM(S): Homo sapiens

SUBMITTER: Libi Hertzberg 

PROVIDER: E-GEOD-17459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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We report gene expression and other analyses to elucidate the molecular characteristics of acute lymphoblastic leukemia (ALL) in children with Down syndrome (DS). We find that by gene expression DS-ALL is a highly heterogeneous disease not definable as a unique entity. Nevertheless, 62% (33/53) of the DS-ALL samples analyzed were characterized by high expression of the type I cytokine receptor CRLF2 caused by either immunoglobulin heavy locus (IgH@) translocations or by interstitial deletions cr  ...[more]

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