Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of mouse motor nerve-stimulated and the contralateral control tabialis anterior muscles

ABSTRACT: Exercise induces skeletal muscle adaptation, and the p38 mitogen-activated protein kinase signaling pathway is thought to play an important role in the adaptive processes. We have obtained new evidence that the gamma isoform of p38 is required for exercise-induced metabolic adaptation in skeletal muscle; however, the neuromuscular activity-dependent target genes of p38gamma remain to be defined. We used microarrays to detail the global programme of gene expression underlying the skeletal muscle genetic reprogramming in response to increased contractile activity and identified distinct classes of up-regulated genes during this process that are dependent on the functional activity of the p38gamma isoform. Skeletal muscle-specific p38gamma knockout mice and the wild type littermates are subject to motor nerve stimulation of one of the tibialis anterior muscles followed by microarray analysis of both the stimulated and the contralateral control muscles.

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Pogozelski 

PROVIDER: E-GEOD-17620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.

Pogozelski Andrew R AR   Geng Tuoyu T   Li Ping P   Yin Xinhe X   Lira Vitor A VA   Zhang Mei M   Chi Jen-Tsan JT   Yan Zhen Z  

PloS one 20091120 11

Regular endurance exercise induces skeletal muscle contractile and metabolic adaptations, conferring salutary health benefits, such as protection against the metabolic syndrome. The plasticity of skeletal muscle has been extensively investigated, but how the adaptive processes are precisely controlled is largely unknown. Using muscle-specific gene deletion in mice, we now show that p38gamma mitogen-activated protein kinase (MAPK), but not p38alpha and p38beta, is required for endurance exercise-  ...[more]

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