Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: hyewon kang
PROVIDER: E-GEOD-17666 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kang Hye Won HW Kanno Keishi K Scapa Erez F EF Cohen David E DE
Biochimica et biophysica acta 20100104 4
Phosphatidylcholine transfer protein (PC-TP, a.k.a. StarD2) is abundantly expressed in liver and is regulated by PPARalpha. When fed the synthetic PPARalpha ligand fenofibrate, Pctp(-/-) mice exhibited altered lipid and glucose metabolism. Microarray profiling of livers from fenofibrate fed wild type and Pctp(-/-) mice revealed differential expression of a broad array of metabolic genes, as well as their regulatory transcription factors. PC-TP expression in cell culture controlled the activities ...[more]