Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Christos Hatzis
PROVIDER: E-GEOD-17705 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Symmans W Fraser WF Hatzis Christos C Sotiriou Christos C Andre Fabrice F Peintinger Florentia F Regitnig Peter P Daxenbichler Guenter G Desmedt Christine C Domont Julien J Marth Christian C Delaloge Suzette S Bauernhofer Thomas T Valero Vicente V Booser Daniel J DJ Hortobagyi Gabriel N GN Pusztai Lajos L
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100809 27
<h4>Purpose</h4>We hypothesize that measurement of gene expression related to estrogen receptor α (ER; gene name ESR1) within a breast cancer sample represents intrinsic tumoral sensitivity to adjuvant endocrine therapy.<h4>Methods</h4>A genomic index for sensitivity to endocrine therapy (SET) index was defined from genes coexpressed with ESR1 in 437 microarray profiles from newly diagnosed breast cancer, unrelated to treatment or outcome. The association of SET index and ESR1 levels with distan ...[more]