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Endocrine Sensitivity Index Validation Dataset

ABSTRACT: Validation dataset of 298 ER-positive patients treated with tamoxifen for 5 years. All patients in this dataset have ER+ breast cancer and were uniformly treated with tamoxifen for 5 years. The objective of the study was to correlate levels of genomic markers to outcomes (relapse free survival) in this cohort of uniformly treated patients. Tissue samples were processed and profiled by two different labs (MD Anderson Cancer Center and Jules Bordet Institute).

ORGANISM(S): Homo sapiens

SUBMITTER: Christos Hatzis

PROVIDER: E-GEOD-17705 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic index of sensitivity to endocrine therapy for breast cancer.

Symmans W Fraser WF Hatzis Christos C Sotiriou Christos C Andre Fabrice F Peintinger Florentia F Regitnig Peter P Daxenbichler Guenter G Desmedt Christine C Domont Julien J Marth Christian C Delaloge Suzette S Bauernhofer Thomas T Valero Vicente V Booser Daniel J DJ Hortobagyi Gabriel N GN Pusztai Lajos L

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100809 27

<h4>Purpose</h4>We hypothesize that measurement of gene expression related to estrogen receptor α (ER; gene name ESR1) within a breast cancer sample represents intrinsic tumoral sensitivity to adjuvant endocrine therapy.<h4>Methods</h4>A genomic index for sensitivity to endocrine therapy (SET) index was defined from genes coexpressed with ESR1 in 437 microarray profiles from newly diagnosed breast cancer, unrelated to treatment or outcome. The association of SET index and ESR1 levels with distan ...[more]

PMID: 20697068

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