Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Endocrine Sensitivity Index Validation Dataset


ABSTRACT: Validation dataset of 298 ER-positive patients treated with tamoxifen for 5 years. All patients in this dataset have ER+ breast cancer and were uniformly treated with tamoxifen for 5 years. The objective of the study was to correlate levels of genomic markers to outcomes (relapse free survival) in this cohort of uniformly treated patients. Tissue samples were processed and profiled by two different labs (MD Anderson Cancer Center and Jules Bordet Institute).

ORGANISM(S): Homo sapiens

SUBMITTER: Christos Hatzis 

PROVIDER: E-GEOD-17705 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Purpose</h4>We hypothesize that measurement of gene expression related to estrogen receptor α (ER; gene name ESR1) within a breast cancer sample represents intrinsic tumoral sensitivity to adjuvant endocrine therapy.<h4>Methods</h4>A genomic index for sensitivity to endocrine therapy (SET) index was defined from genes coexpressed with ESR1 in 437 microarray profiles from newly diagnosed breast cancer, unrelated to treatment or outcome. The association of SET index and ESR1 levels with distan  ...[more]

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