Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chelsee Hewitt
PROVIDER: E-GEOD-17760 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hewitt Chelsee A CA Ling King-Hwa KH Merson Tobias D TD Simpson Ken M KM Ritchie Matthew E ME King Sarah L SL Pritchard Melanie A MA Smyth Gordon K GK Thomas Tim T Scott Hamish S HS Voss Anne K AK
PloS one 20100716 7
<h4>Background</h4>Down syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease.<h4>Methodology/principal findings</h4>To understand how trisomy 21 causes these neurological abnormalities we investigated changes in gene expression networks combined with a systematic cell lineage analysis of adult neurogenesis using the Ts1Cje mouse model of DS. We demonstrated down regulation of a number of key genes involved in proliferation and cel ...[more]