C. elegans small RNAs
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Eugene Berezikov
PROVIDER: E-GEOD-17787 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs.
van Wolfswinkel Josien C JC Claycomb Julie M JM Batista Pedro J PJ Mello Craig C CC Berezikov Eugene E Ketting René F RF
Cell 20091001 1
We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1 localizes specifically to mitotic chromosomes in embryos. This localization requires the RdRP EGO-1, which physically interacts with CDE-1, and the Argonaute protein CSR-1. We found that CDE-1 is required for the uridylation of CSR-1 bound siRNAs, and that in the absence of CDE-1 these siRNAs accumulate to inappropriate levels, accompanied b ...[more]
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