Dataset Information
Transcription profiling of rat amygdala following anesthesia with isoflurane, pain or following fear conditioning in the presence and absence of isofluran
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Ira Rampil
PROVIDER: E-GEOD-1779 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Isoflurane modulates genomic expression in rat amygdala.
Anesthesia and analgesia 20060501 5
General anesthesia, at a minimum, provides amnesia and unresponsiveness. Although anesthetics have many modulatory effects on neuronal ionophore protein complexes, it is not clear that the resulting electrophysiologic changes are the sole mechanisms of clinical anesthetic action. Cells respond to environmental changes in several ways, including alterations in DNA transcription leading to changes in the cell's proteins. We sought to expose the changes in global genomic expression, seeking potenti ...[more]
