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Somatic Mutation Screen of Clear Cell RCC I

ABSTRACT: Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic mutations in each sample can be found at http://www.sanger.ac.uk/genetics/CGP/Studies/. These samples were run at a different facility than VARI - scmmlab.com Correlating gene expression profiling with mutational status

ORGANISM(S): Homo sapiens

SUBMITTER: Karl Dykema 

PROVIDER: E-GEOD-17816 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

Dalgliesh Gillian L GL   Furge Kyle K   Greenman Chris C   Chen Lina L   Bignell Graham G   Butler Adam A   Davies Helen H   Edkins Sarah S   Hardy Claire C   Latimer Calli C   Teague Jon J   Andrews Jenny J   Barthorpe Syd S   Beare Dave D   Buck Gemma G   Campbell Peter J PJ   Forbes Simon S   Jia Mingming M   Jones David D   Knott Henry H   Kok Chai Yin CY   Lau King Wai KW   Leroy Catherine C   Lin Meng-Lay ML   McBride David J DJ   Maddison Mark M   Maguire Simon S   McLay Kirsten K   Menzies Andrew A   Mironenko Tatiana T   Mulderrig Lee L   Mudie Laura L   O'Meara Sarah S   Pleasance Erin E   Rajasingham Arjunan A   Shepherd Rebecca R   Smith Raffaella R   Stebbings Lucy L   Stephens Philip P   Tang Gurpreet G   Tarpey Patrick S PS   Turrell Kelly K   Dykema Karl J KJ   Khoo Sok Kean SK   Petillo David D   Wondergem Bill B   Anema John J   Kahnoski Richard J RJ   Teh Bin Tean BT   Stratton Michael R MR   Futreal P Andrew PA  

Nature 20100106 7279

Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer, characterized by the presence of inactivating mutations in the VHL gene in most cases, and by infrequent somatic mutations in known cancer genes. To determine further the genetics of ccRCC, we have sequenced 101 cases through 3,544 protein-coding genes. Here we report the identification of inactivating mutations in two genes encoding enzymes involved in histone modification-SETD2, a histone H3 lysine 36 methy  ...[more]

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