Integrating phenotypic and expression profiles to map arsenic response networks
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Trey Ideker
PROVIDER: E-GEOD-1798 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Integrating phenotypic and expression profiles to map arsenic-response networks.
Haugen Astrid C AC Kelley Ryan R Collins Jennifer B JB Tucker Charles J CJ Deng Changchun C Afshari Cynthia A CA Brown J Martin JM Ideker Trey T Van Houten Bennett B
Genome biology 20041129 12
<h4>Background</h4>Arsenic is a nonmutagenic carcinogen affecting millions of people. The cellular impact of this metalloid in Saccharomyces cerevisiae was determined by profiling global gene expression and sensitivity phenotypes. These data were then mapped to a metabolic network composed of all known biochemical reactions in yeast, as well as the yeast network of 20,985 protein-protein/protein-DNA interactions.<h4>Results</h4>While the expression data unveiled no significant nodes in the metab ...[more]
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