An Estrogen Receptor α-bound Human Chromatin Interactome
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yijun Ruan
PROVIDER: E-GEOD-18046 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
An oestrogen-receptor-alpha-bound human chromatin interactome.
Fullwood Melissa J MJ Liu Mei Hui MH Pan You Fu YF Liu Jun J Xu Han H Mohamed Yusoff Bin YB Orlov Yuriy L YL Velkov Stoyan S Ho Andrea A Mei Poh Huay PH Chew Elaine G Y EG Huang Phillips Yao Hui PY Welboren Willem-Jan WJ Han Yuyuan Y Ooi Hong Sain HS Ariyaratne Pramila N PN Vega Vinsensius B VB Luo Yanquan Y Tan Peck Yean PY Choy Pei Ye PY Wansa K D Senali Abayratna KD Zhao Bing B Lim Kar Sian KS Leow Shi Chi SC Yow Jit Sin JS Joseph Roy R Li Haixia H Desai Kartiki V KV Thomsen Jane S JS Lee Yew Kok YK Karuturi R Krishna Murthy RK Herve Thoreau T Bourque Guillaume G Stunnenberg Hendrik G HG Ruan Xiaoan X Cacheux-Rataboul Valere V Sung Wing-Kin WK Liu Edison T ET Wei Chia-Lin CL Cheung Edwin E Ruan Yijun Y
Nature 20091101 7269
Genomes are organized into high-level three-dimensional structures, and DNA elements separated by long genomic distances can in principle interact functionally. Many transcription factors bind to regulatory DNA elements distant from gene promoters. Although distal binding sites have been shown to regulate transcription by long-range chromatin interactions at a few loci, chromatin interactions and their impact on transcription regulation have not been investigated in a genome-wide manner. Here we ...[more]
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