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Microarray of RNA from calvaria in WT and OASIS-/- (KO) mice

ABSTRACT: Investigation of whole genome gene expression level changes in OASIS KO calvaria compared to wild-type calvaria. To gain further insight into the potential mechanisms underlying the defective bone formation in OASIS KO mice, we compared the gene expression in calvaria between WT and OASIS KO mice using a microarray. Each sample of total RNA was collected from a number of mice.

ORGANISM(S): Mus musculus

SUBMITTER: Imaizumi Kazunori

PROVIDER: E-GEOD-18062 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.

Murakami Tomohiko T Saito Atsushi A Hino Shin-ichiro S Kondo Shinichi S Kanemoto Soshi S Chihara Kazuyasu K Sekiya Hiroshi H Tsumagari Kenji K Ochiai Kimiko K Yoshinaga Kazuya K Saitoh Masahiro M Nishimura Riko R Yoneda Toshiyuki T Kou Ikuyo I Furuichi Tatsuya T Ikegawa Shiro S Ikawa Masahito M Okabe Masaru M Wanaka Akio A Imaizumi Kazunori K

Nature cell biology 20090920 10

Eukaryotic cells have signalling pathways from the endoplasmic reticulum (ER) to cytosol and nuclei, to avoid excess accumulation of unfolded proteins in the ER. We previously identified a new type of ER stress transducer, OASIS, a bZIP (basic leucine zipper) transcription factor, which is a member of the CREB/ATF family and has a transmembrane domain. OASIS is processed by regulated intramembrane proteolysis (RIP) in response to ER stress, and is highly expressed in osteoblasts. OASIS(-/-) mice ...[more]

PMID: 19767743

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