Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Akiko Doi
PROVIDER: E-GEOD-18226 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Doi Akiko A Park In-Hyun IH Wen Bo B Murakami Peter P Aryee Martin J MJ Irizarry Rafael R Herb Brian B Ladd-Acosta Christine C Rho Junsung J Loewer Sabine S Miller Justine J Schlaeger Thorsten T Daley George Q GQ Feinberg Andrew P AP
Nature genetics 20091101 12
Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine (CpG) island shores in nine human iPS cell lines as compared to their parental fibroblasts. The differentially methylated regions (DMRs) in the reprogrammed cells (denoted R-DMRs) were significantly enriched in tissue-specific (T-DMRs; 2.6-fol ...[more]