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Liver gene expression from chromogranin A knockout mice (Mahapatra et al. 2005) vs. wild-type mice

ABSTRACT: The objective of the experiment is to determine the genes differentially expressed in the liver of the chromogranin A knockout mouse (Mahapatra et al., 2005). Liver from chromogranin A knockout mice (n=3) and wild-type control mice (n=3).

ORGANISM(S): Mus musculus

SUBMITTER: Ryan Friese 

PROVIDER: E-GEOD-18305 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verification.

Friese Ryan S RS   Gayen Jiaur R JR   Mahapatra Nitish R NR   Schmid-Schönbein Geert W GW   O'Connor Daniel T DT   Mahata Sushil K SK  

Physiological genomics 20091201 3

Chromogranin A (CHGA) has a crucial role in formation of regulated secretory granules in neuroendocrine tissues and is also a prohormone that is proteolytically processed into peptides with diverse and complex actions. CHGA and several of its peptide products, including catestatin and pancreastatin, are implicated in pathogenesis of essential hypertension, insulin resistance, and the metabolic syndrome. The Chga knockout mouse (Chga KO) displays severe hypertension coupled with reduction in size  ...[more]

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