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Transcription profiling of human vastus lateralis muscle from exercised and non-exercised subjects

ABSTRACT: Four healthy human volunteers underwent an acute bout of resistance exercise with the right leg at 2 pm. Biopsies were removed from the Vastus Lateralis muscle 6 h (8 pm) and 18 h (8 am) after exericise

ORGANISM(S): Homo sapiens

SUBMITTER: Alexander Zambon

PROVIDER: E-GEOD-1832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Time- and exercise-dependent gene regulation in human skeletal muscle.

Zambon Alexander C AC McDearmon Erin L EL Salomonis Nathan N Vranizan Karen M KM Johansen Kirsten L KL Adey Deborah D Takahashi Joseph S JS Schambelan Morris M Conklin Bruce R BR

Genome biology 20030925 10

<h4>Background</h4>Skeletal muscle remodeling is a critical component of an organism's response to environmental changes. Exercise causes structural changes in muscle and can induce phase shifts in circadian rhythms, fluctuations in physiology and behavior with a period of around 24 hours that are maintained by a core clock mechanism. Both exercise-induced remodeling and circadian rhythms rely on the transcriptional regulation of key genes.<h4>Results</h4>We used DNA microarrays to determine the ...[more]

PMID: 14519196

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Time and Exercise effects on Human Skeletal Muscle

Project description:Four healthy human volunteers underwent an acute bout of resistance exercise with the right leg at 2 pm. Biopsies were removed from the Vastus Lateralis muscle 6 h (8 pm) and 18 h (8 am) after exericise Keywords = Human skeletal muscle Keywords = resistance exerise Keywords = diurnal Keywords = circadian Keywords: time-course

2004-10-14 | GSE1832 | GEO

Gene Expression in Human Vastus Lateralis after PrimaVie Shilajit Supplementation

Project description:Changes in Gene exporession after 8 weeks of PrimaVie Shilajit Supplementation were measured in vastus lateralis GeneChip® Human Transcriptome Array 2.0 was used to study the gene expression in human vastus lateralis after supplementation of PrimaVie Shilajit and identified distinct classes of up-regulated genes during this process.

2017-03-01 | GSE71219 | GEO

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Project description:Needle biopsies were obtained from the vastus lateralis muscle of 6 healthy, sedentary, 67±2.5 year-old males before and after 3 months of training. Keywords: other

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Vastus lateralis muscle biopsy: post-expedition vs. pre-expedition

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2010-11-27 | E-GEOD-25618 | biostudies-arrayexpress

Vastus lateralis muscle biopsy: post-expedition vs. pre-expedition

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Muscle Transcriptome Profile of Resistance Exercise is Augmented by Aerobic Exercise

Project description:10 male subjects performed ~45 min one-legged cycling and 4 x 7 maximal concentric-eccentric knee extensions for each leg 15 min later. Thus, one limb performed aerobic and resistance exercise (AE+RE), while the opposing leg did resistance exercise only (RE). Biopsies were obtained from m. vastus lateralis of each leg 3 h after the resistance exercise bout. Gene expression analysis was carried out on the Affymetrix HuGene-2.1-st platform.

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Vastus lateralis muscle aging

Project description:Development of a method to identify age-regulated expression trends in skeletql muscles and study the underlying molecular processes of the age_associated progressive changes in skeletal muscles. See abstract from associated manuscript belowÂ : Aging is characterized by progressive tissue degeneration and it is associated with genome-wide changes of mRNA expression profiles. Therefore, it is expected that age-regulated changes in expression profiles could describe the process of aging. We have developed a robust and unbiased methodology to identify age-regulated expression trends in cross-sectional data sets from healthy donors. Our analysis in four different tissues reveals that in brain cortex and Vastus lateralis muscles, two major age-associated expression inclinations were found, one during midlife and one in elderly. In kidney medulla and cortex, however, transcriptional changes were found only in elderly. In concurrence with increased degeneration in aged tissue, the elderly-associated expression changes are predominantly downwards. Our results suggest that a non-linear trend describes the aging process, and can be the result of inclinations of gene expression at two distinct age-positions affecting different molecular and cellular processes. RNA was extracted from vastus lateralis muscles. cDNA synthesis and labeling were preformed with the Illumina cDNA labeling kit.

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2019-07-03 | GSE133720 | GEO

Vastus lateralis muscle of patients with an acute COPD exacerbation

Project description:To further unravel the potential molecular mechanisms involved in the loss of muscle function during an acute exacerbation, a cross-sectional microarray study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable COPD patients. Keywords: cross-sectional patient study A cross-sectional microarray study was designed. The microarray screening was performed on a vastus lateralis biopsy obtained from 4 patients with an acute COPD exacerbation and 5 stable COPD patients. No replicates or dye-swaps were included.

2009-03-13 | E-GEOD-10828 | biostudies-arrayexpress

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