Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Danette Hartzell
PROVIDER: E-GEOD-18347 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
BMC genomics 20091027
<h4>Background</h4>Regulation of gene expression is essential for normal development and cellular growth. Transcriptional events are tightly controlled both spatially and temporally by specific DNA-protein interactions. In this study we finely map the genome-wide targets of the CREB protein across all known and predicted human promoters, and characterize the functional consequences of a subset of these binding events using high-throughput reporter assays. To measure CREB binding, we used HaloCHI ...[more]