Unknown,Transcriptomics,Genomics,Proteomics

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Differential functional effects of EGF along the human fetal intestine


ABSTRACT: Transcriptional profiling of small and large intestinal explants cultured in the absence or in the presence of EGF (50 ng/mL). Two-condition experiment, control intestinal explants vs EGF intestinal explants

ORGANISM(S): Homo sapiens

SUBMITTER: Jean-François Beaulieu 

PROVIDER: E-GEOD-18367 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Anti-inflammatory effects of epidermal growth factor on the immature human intestine.

Ménard Daniel D   Tremblay Eric E   Ferretti Emanuela E   Babakissa Corentin C   Perron Nancy N   Seidman Ernest G EG   Levy Emile E   Beaulieu Jean-François JF  

Physiological genomics 20120103 4


The inflammatory response of the preterm infants' intestine underlines its inability to respond to hemodynamic stress, microbes, and nutrients. Recent evidence suggests that exogenous epidermal growth factor (EGF) exerts a therapeutic influence on neonatal enteropathies. However, the molecular mechanisms underlying the beneficial effects of EGF remain to be clarified. The purpose of this study was to evaluate the impact of EGF on the gene expression profiles of the developing human small and lar  ...[more]

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