Dataset Information
Gene expression profiling of human DLBCL tumor samples (SGN-40 trial)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Peng Yue
PROVIDER: E-GEOD-18376 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma.
Science translational medicine 20110301 74
The primary function of B cells, critical components of the adaptive immune response, is to produce antibodies against foreign antigens, as well as to perform isotype class switching, which changes the heavy chain of an antibody so that it can interact with different repertoires of effector cells. CD40 is a member of the tumor necrosis factor superfamily of cell surface receptors that transmits survival signals to B cells. In contrast, in B cell cancers, stimulation of CD40 signaling results in ...[more]
