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Dmrt1 (doublesex and mab-3 related transcription factor 1) knockout expression analyses in E13.5 testes in S6 background

ABSTRACT: Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development in vertebrates. In mice of the 129Sv strain, loss of Dmrt1 causes a high incidence of teratomas. Mutant 129Sv germ cells undergo apparently normal differentiation up to embryonic day 13.5 (E13.5), but some cells fail to arrest mitosis and ectopically express pluripotency markers. Expression analysis and chromatin immunoprecipitation identified DMRT1 target genes whose misexpression may underly teratoma formation. Comparison of E13.5 testes gene expression between Dmrt1(+/-) and Dmrt1(-,-) animals that show high incidence of teratoma formation.

ORGANISM(S): Mus musculus

SUBMITTER: Aaron Sarver 

PROVIDER: E-GEOD-18396 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.

Krentz Anthony D AD   Murphy Mark W MW   Kim Shinseog S   Cook Matthew S MS   Capel Blanche B   Zhu Rui R   Matin Angabin A   Sarver Aaron L AL   Parker Keith L KL   Griswold Michael D MD   Looijenga Leendert H J LH   Bardwell Vivian J VJ   Zarkower David D  

Proceedings of the National Academy of Sciences of the United States of America 20091210 52

Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development in vertebrates. Here, we show that in mice of the 129Sv strain, loss of Dmrt1 causes a high incidence of teratomas, whereas these tumors do not form in Dmrt1 mutant C57BL/6J mice. Conditional gene targeting indicates that Dmrt1 is required in fetal germ cells but not in Sertoli cells to prevent teratoma formation. Mutant 129Sv germ cells  ...[more]

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