Identification and validation of causal genes for atherosclerosis in mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Xia Yang
PROVIDER: E-GEOD-18479 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Identification and validation of genes affecting aortic lesions in mice.
Yang Xia X Peterson Larry L Thieringer Rolf R Deignan Joshua L JL Wang Xuping X Zhu Jun J Wang Susanna S Zhong Hua H Stepaniants Serguei S Beaulaurier John J Wang I-Ming IM Rosa Ray R Cumiskey Anne-Marie AM Luo Jane Ming-Juan JM Luo Qi Q Shah Kashmira K Xiao Jianying J Nickle David D Plump Andrew A Schadt Eric E EE Lusis Aldons J AJ Lum Pek Yee PY
The Journal of clinical investigation 20100623 7
Atherosclerosis represents the most significant risk factor for coronary artery disease (CAD), the leading cause of death in developed countries. To better understand the pathogenesis of atherosclerosis, we applied a likeli-hood-based model selection method to infer gene-disease causality relationships for the aortic lesion trait in a segregating mouse population demonstrating a spectrum of susceptibility to developing atherosclerotic lesions. We identified 292 genes that tested causal for aorti ...[more]
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