Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human lung and tonsillar mast cells


ABSTRACT: GeneChip Data of human lung mast cells and tonsillar mast cells

ORGANISM(S): Homo sapiens

SUBMITTER: Yoshimichi Okayama 

PROVIDER: E-GEOD-1848 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells.

Kashiwakura Jun-ichi J   Yokoi Hidenori H   Saito Hirohisa H   Okayama Yoshimichi Y  

Journal of immunology (Baltimore, Md. : 1950) 20041001 8


Mast cells (MCs) are the primary effector cells in allergic reactions and have also been found to activate T cells and to reside in close physical proximity to T cells. However, the molecular mechanisms involved in the MC-T cell interaction remain unclear. We hypothesized that human tonsillar MCs, which locate in the interfollicular areas, might interact with T cells. Thus, we first established a culture system of human tonsillar MCs and then compared gene expression profiles of tonsillar MCs wi  ...[more]

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