Gene Analysis of Rasagiline
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yotam Sagi
PROVIDER: E-GEOD-1856 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism.
Sagi Yotam Y Mandel Silvia S Amit Tamar T Youdim Moussa B H MB
Neurobiology of disease 20061020 1
The anti-Parkinson monoamine oxidase (MAO)-B inhibitor rasagiline (Azilect) was shown to possess neuroprotective activities, involving the induction of brain-derived- and glial cell line-derived neurotrophic factors (BDNF, GDNF). Employing conventional neurochemical techniques, transcriptomics and proteomic screening tools combined with a biology-based clustering method, we show that rasagiline, given chronically post-MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), exerts neurorescue/neurot ...[more]
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