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Drosophila 16-20 hrs embryos: DHR3G60S/Df(2R)12 vs. w1118

ABSTRACT: Transcriptional profiling of 16-20 hrs Drosophila embryos comparing control (w1118) and DHR3 mutants (DHR3G60S/Df(2R)12) Two-condition experiment, control vs. DHR3 mutant embryos. Biological replicates: 4 replicates.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Anne-FranÃ§oise Ruaud

PROVIDER: E-GEOD-18577 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos.

Ruaud Anne-Françoise AF Lam Geanette G Thummel Carl S CS

Development (Cambridge, England) 20100101 1

Studies of the onset of metamorphosis have identified an ecdysone-triggered transcriptional cascade that consists of the sequential expression of the transcription-factor-encoding genes DHR3, betaFTZ-F1, E74A and E75A. Although the regulatory interactions between these genes have been well characterized by genetic and molecular studies over the past 20 years, their developmental functions have remained more poorly understood. In addition, a transcriptional sequence similar to that observed in pr ...[more]

PMID: 20023167

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