Baseline skeletal muscle gene expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Steen Knudsen
PROVIDER: E-GEOD-18583 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
Timmons James A JA Knudsen Steen S Rankinen Tuomo T Koch Lauren G LG Sarzynski Mark M Jensen Thomas T Keller Pernille P Scheele Camilla C Vollaard Niels B J NB Nielsen Søren S Akerström Thorbjörn T MacDougald Ormond A OA Jansson Eva E Greenhaff Paul L PL Tarnopolsky Mark A MA van Loon Luc J C LJ Pedersen Bente K BK Sundberg Carl Johan CJ Wahlestedt Claes C Britton Steven L SL Bouchard Claude C
Journal of applied physiology (Bethesda, Md. : 1985) 20100204 6
A low maximal oxygen consumption (VO2max) is a strong risk factor for premature mortality. Supervised endurance exercise training increases VO2max with a very wide range of effectiveness in humans. Discovering the DNA variants that contribute to this heterogeneity typically requires substantial sample sizes. In the present study, we first use RNA expression profiling to produce a molecular classifier that predicts VO2max training response. We then hypothesized that the classifier genes would har ...[more]
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Project description:Muscle biopsy samples were obtained from two groups of male subjects prior to endurance training. The samples were used to predict training responses. Baseline gene expression involving 30 probe sets was able to classify subjects into high and low responders.
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