Unknown,Transcriptomics,Genomics,Proteomics

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Changes in expression of small non-coding RNAs/microRNAs during aging in C. elegans


ABSTRACT: We report a significant number of miRNAs and other non-coding small RNAs show dramatic changes in expression during aging in C. elegans. RNAs were prepared from four diffrent timepoints during adulthood of C. elegans hermaphrodites, Day 0, 5, 8 and 12 post-L4 molt, and used for making cDNA libraries for small RNAs. Each library was sequenced using recent advances in high-throughput sequencing technology, Solexa. This study should lead to a better understanding of the aging process and age-related diseases. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf Examination of small RNA expression in four timepoints during adulthood of C. elegans hermaphrodites (spe-9 (hc88), cultured at 23dC), Day 0, 5, 8 and 12 post L4-molt.

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Frank Slack 

PROVIDER: E-GEOD-18634 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.

Kato Masaomi M   Chen Xiaowei X   Inukai Sachi S   Zhao Hongyu H   Slack Frank J FJ  

RNA (New York, N.Y.) 20110802 10


Small, noncoding RNAs (sncRNAs), including microRNAs (miRNAs), impact diverse biological events through the control of gene expression and genome stability. However, the role of these sncRNAs in aging remains largely unknown. To understand the contribution of sncRNAs to the aging process, we performed small RNA profiling by deep-sequencing over the course of Caenorhabditis elegans (C. elegans) aging. Many small RNAs, including a significant number of miRNAs, change their expression during aging  ...[more]

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