Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Eran Tauber
PROVIDER: E-GEOD-18644 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tauber Eran E Miller-Fleming Leonor L Mason Robert P RP Kwan Wanda W Clapp Jannine J Butler Nicola J NJ Outeiro Tiago F TF Muchowski Paul J PJ Giorgini Flaviano F
The Journal of biological chemistry 20101102 1
Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (htt) protein. To uncover candidate therapeutic targets and networks involved in pathogenesis, we integrated gene expression profiling and functional genetic screening to identify genes critical for mutant htt toxicity in yeast. Using mRNA profiling, we have identified genes differentially expressed in wild-type yeast in response to mutant htt toxicity as well as in three to ...[more]